Endocrine Abstracts

Introduction: Hypothyroidism can present in a variety of ways, from unexpected abnormal blood results in seemingly asymptomatic patients to those with a multitude of debilitating symptoms. Levothyroxine dose titration is a challenge often faced by physicians. We identified 8 difficult cases which following MDT discussion underwent the Thyroxine Absorption Test (TAT) to gain further clarification (Walker et al. 2013).Aim: To identify if the issue...

The prevalence of adrenal incidentaloma on abdominal Computed Tomography (CT) is around 4.4%. This prevalence is increased in obese, diabetic, hypertensive patients, and could be as high as 10% in older patients. Unilateral adrenal masses larger than 4 cm should be considered for surgical removal to avoid missing adrenal carcinoma, particularly in younger patients.This is the case of a 67 year old gentleman with Type 2 diabetes mellitus, known to have hy...

Aim: The aim of this study was to estimate the frequency of SMBG among patients attending a tertiary care hospital and to evaluate the impact of SMBG on glycemic control in participants with diabetes mellitus.Method: A random sample of 174 patients was selected for accrual in the study from the diabetic clinic of Nishtar Medical College Hospital Multan. Patients were interviewed using a structured questionnaire to elicit information about their self mana...

Buffalo is a major dairy animal in many countries of the world, including Pakistan. However, the productive and reproductive performance of this species is affected by many physiological problems such as anestrous. Therefore, this study was conducted to compare serum total cholesterol, thyroid hormone concentrations and haematological variables in cyclic and acyclic Nili-Ravi buffaloes. For this purpose, 60 adult Nili-Ravi buffaloes were divided into two equal groups i.e. cycl...

Diabetic nephropathy is the leading cause of chronic kidney disease and is responsible for 30–40% of all end stage renal disease (1). Where there is rapid decline in eGFR, we should also consider other aetiologies.This is the case of a 65-year-old Caucasian gentleman with complex presentation and novel management strategy with type 2 diabetes mellitus since 1999 which was effectively managed, evident by reasonable control of HBA1c; Pharmacotherapy r...

An 88-year-old Caucasian man with hypertension, single functioning kidney, vitamin D insufficiency and transurethral resection of the prostate was admitted with worsening confusion. On admission, he had acute on chronic renal impairment (Urea- 17.2 mmol/l (range: 2.5–7.5 mmol/l), Creatinine- 163 μmol/l (range: 60–120 μmol/l), eGFR- 35 (Baseline- 60 ml/min/1.73m2) and a normal serum/corrected calcium (2.51 mmol/l (range- 2.2–2.6mmol/l). He wa...

Background and aim: Serum Cystatin C has been shown to be associated with the progression to prediabetes and type 2 diabetes mellitus. High cystatin levels were also found to be associated with body mass index. The aim of this study was to evaluate cystatin C levels in diabetic and prediabetic patients ant its association with anthropometric measurements and insulin resistance.Methods: Twenty four patients with diabetes, 17 patients with prediabetes and ...

Introduction: Green tea consumption has been reported to be associated with weight loss although the results of the studies are inconclusive and potential underlying mechanism is not yet clear. We aimed to evaluate the effect of green tea extract on weight loss, body composition and resting energy expenditure in obesity.Methods: Twenty-nine obese patients (body mass index (BMI) >30 kg/m2) were included in the study. Weight, BMI, waist circ...

Background and aim: Subclinical hypothyrodism (SH) appears to be associated with mood and changes. The aims of this study were: i) to determine whether depression is more common in SH, and ii) to investigate the effects of L-thyroxine (LT4) therapy on depressive symptoms.Methods: 31 patients with SH and 36 age amd BMI matched healthy controls were included. Beck and Hamilton scales were used to evaluate depression...

Introduction: Visceral adipose tissue-derived serine protease inhibitor (vaspin) is a novel adipocytokine which might exert an insulin-sensitizing effect. It is thought that vaspin mRNA expression may be a compensatory mechanism associated with obesity and insulin resistance. Given the fact that subclinical and overt hypothyroidism are known risk factors for insulin resistance, we aimed to assess the regulation of vaspin by thyroid hormones in humans.Met...